DECOMICS

DECOMICS performs unsupervised cell type deconvolution and biological interpretation of bulk transcriptome or methylome data through a modular web application framework.

Key Features:

• Deconvolution Algorithms: Provides multiple existing algorithms for deconvolution of gene expression or methylation-level matrices.
• Enrichment Analysis Module: Performs enrichment analysis to aid biological interpretation of deconvolved components.
• Visualization Tools: Includes tools for visualizing deconvolution and enrichment results.
• Data Preprocessing: Supports normalization, transformation, and feature selection of input data matrices.
• Data Export: Allows download of deconvolution, enrichment, and visualization results.

Scientific Applications:

• Cell Composition Estimation: Estimates and identifies cell type composition from bulk tissue transcriptomes or methylomes without reference profiles.
• Biological Interpretation: Interprets deconvolved cell type components through functional enrichment analysis.
• Bulk Omics Analysis: Applies to both bulk gene expression and DNA methylation data.

Methodology:

DECOMICS accepts csv format input data which can be preprocessed through normalization, transformation, and feature selection within the application. The tool applies unsupervised deconvolution algorithms to gene expression or methylation-level matrices, followed by enrichment analysis for biological interpretation of components.