DecoPath

DecoPath compares and visualizes pathway enrichment analysis results to assess consensus and discrepancies across multiple pathway databases and enrichment methods.

Key Features:

• Pathway enrichment analysis: Performs pathway enrichment analyses or accepts uploaded enrichment results for comparative interpretation.
• Cross-database comparison: Compares and integrates results across multiple pathway databases to evaluate redundancy and interoperability.
• Multi-method comparison: Compares outcomes from different enrichment methods to identify method-dependent variability.
• Consensus and discrepancy visualization: Generates custom visualizations that delineate consensus and discrepancies at both pathway and gene levels.
• Resource selection support: Exposes differences and agreements across databases and methods to inform selection of appropriate resources.

Scientific Applications:

• Comparative pathway enrichment analysis: Assess concordance of pathway enrichment results across databases and enrichment methods.
• Pathway- and gene-level interpretation: Interpret biological relevance by examining consensus and discrepancies at pathway and gene levels.
• Database interoperability evaluation: Evaluate redundancy and lack of consensus among pathway databases to guide database selection.
• Experimental design guidance: Inform choice of pathway databases and enrichment methods during experimental design.

Methodology:

Performs pathway enrichment analyses and comparative integration of results across pathway databases and enrichment methods, and produces custom visualizations that delineate consensus and discrepancies at pathway and gene levels; accepts uploaded enrichment results for comparative interpretation.