DeMBA

DeMBA encompasses every postnatal day from 4 to 56 as a 4D atlas of the developing mouse brain, providing age-specific spatial frameworks for spatial registration, analysis, and brain-wide quantification of features during development.

Key Features:

• 4D Atlas Coverage: The atlas spans postnatal days 4 to 56, representing every postnatal day through interpolation between six developmental time point templates.
• Spatial Registration and Analysis: DeMBA is incorporated in software enabling brain-wide quantification of features of interest.
• CCF Translator: A software package allowing coordinates or image volumes to be transformed between ages for comparison across developmental time points.

Scientific Applications:

• Developmental Brain Quantification: Enables brain-wide quantification of features of interest across postnatal mouse brain development.
• Cross-Age Comparison: Allows researchers to compare data across developmental ages through coordinate and image volume transformation.
• Data Integration: Provides standardized spatial frameworks for analysis and integration of developmental mouse brain data.

Methodology:

DeMBA was created by using existing brain templates for six developmental time points and interpolating intermediate ages.