DemoTox-PK

DemoTox-PK visualizes pharmacokinetic and toxicodynamic alterations to elucidate mechanisms underlying idiosyncratic drug-induced liver injury (IDILI).

Key Features:

• Visualization of pharmacokinetic and toxicodynamic alterations: Visualizes how changes in pharmacokinetics (drug metabolism alterations, transporter polymorphisms) and toxicodynamics (mitochondrial injury, accumulation of toxic endogenous factors, harmful immune responses) can contribute to IDILI.
• Graphical illustration of pathogenesis hypotheses: Represents mechanistic hypotheses linking specific PK and TD alterations to IDILI to facilitate mechanistic interpretation.
• Mechanism-based biomarker and target support: Highlights mechanistic links between PK/TD alterations and liver injury to support identification and prioritization of potential biomarkers and therapeutic targets.

Scientific Applications:

• IDILI pathogenesis research: Examines how alterations in drug metabolism, transporter polymorphisms, mitochondrial injury, endogenous toxic factor accumulation, or immune responses contribute to liver injury.
• Biomarker and therapeutic target identification: Aids prioritization of mechanistic biomarkers and therapeutic targets based on illustrated PK/TD mechanisms.
• Education and training: Provides graphical representations of pharmacokinetic and toxicodynamic concepts to support instruction on drug-induced liver toxicities.

Methodology:

Graphical illustration of pharmacokinetic and toxicodynamic concepts related to IDILI.