diffUTR

diffUTR detects differential exon usage (DEU) focusing on 3' untranslated region (3' UTR) variations and alternative polyadenylation from standard transcriptomic data and is implemented as an R package.

Key Features:

• Streamlined DEU Analysis: Integrates existing DEU tools to identify differential exon usage with specific attention to 3' UTR events from transcriptomic data.
• Enhanced Accuracy and Flexibility: Demonstrated increased flexibility and accuracy compared to state-of-the-art alternatives in simulated and real datasets.
• Leveraging Databases: Utilizes databases of alternative polyadenylation sites alongside established DEU methods to enable comprehensive differential 3' UTR usage analysis.

Scientific Applications:

• Exploration of Biological Phenomena: Study the implications of alternative polyadenylation and 3' UTR length variation for gene regulation.
• Facilitation of DEU Research: Enable differential 3' UTR analysis and support investigations into exon usage differences across conditions.

Methodology:

Leverages existing computational DEU tools and databases of alternative polyadenylation sites to analyze transcriptomic data.