Dintor

Dintor provides functional annotation and integration of genomic and proteomic datasets to support analyses of gene function, orthology, genetic variant effects, and protein annotations.

Key Features:

• Extensive toolset: A collection of over 30 specialized tools that can be used individually or combined into complex data processing pipelines.
• Functional annotation capabilities: Gene identifier conversions, orthology mappings, functional annotation of proteins and genetic variants, candidate gene prioritization, and Gene Ontology-based gene set enrichment analysis.
• Data versioning and reproducibility: Management of multiple archived dataset versions with links between tools and specific dataset versions to ensure reproducible analyses.
• Modular integration: Modular tools enable integration of heterogeneous genomic and proteomic datasets into customized analytical workflows.

Scientific Applications:

• Gene function annotation: Functional characterization of genes and proteins through integrated annotations and Gene Ontology enrichment.
• Variant impact and prioritization: Annotation and prioritization of genetic variants for downstream analysis and candidate gene selection.
• Protein annotation and proteomics integration: Functional annotation of proteins and integration with proteomic datasets.
• Comparative genomics and orthology studies: Orthology mapping to support comparative analyses across species.
• Integrative analyses of large-scale experiments: Integration and reproducible analysis of heterogeneous datasets from large-scale sequencing and proteomics studies.

Methodology:

Modular combination of >30 tools into pipelines performing gene identifier conversion, orthology mapping, functional annotation of proteins and genetic variants, candidate gene prioritization, Gene Ontology-based gene set enrichment analysis, integration of heterogeneous genomic and proteomic datasets, and management of archived dataset versions linked to specific tool runs.