Dinucleotide property database (DiProDB)

Dinucleotide property database (DiProDB) provides a curated collection of conformational and thermodynamic dinucleotide property datasets for DNA and RNA to support sequence encoding, structural modeling, and thermodynamic analysis.

Key Features:

• Extensive Data Collection: Contains dinucleotide conformational and thermodynamic properties for DNA and RNA, including single-stranded and double-stranded contexts.
• Correlation Analysis Facility: Provides built-in correlation analysis of property datasets to identify highly correlated dinucleotide parameters.
• Data Submission and Expansion: Accepts contributed dinucleotide property datasets from authors to expand and update the repository.
• Sequence Encoding Application: Stores properties suitable for encoding nucleic acid sequences for bioinformatics analyses and prediction models.
• Data Pruning and Rearrangement: Supports dynamic pruning and rearrangement of data tables based on specified criteria.
• Export and Analysis Functions: Offers multiple export and analysis functions for integration with other bioinformatics workflows.

Scientific Applications:

• Structural Biology: Uses dinucleotide property datasets to model and predict DNA and RNA three-dimensional structures.
• Thermodynamics Studies: Uses thermodynamic dinucleotide parameters to analyze nucleic acid stability and interactions.
• Bioinformatics: Employs dinucleotide encodings for sequence analysis tasks such as motif discovery and comparative genomics.

Methodology:

Datasets are compiled through rigorous data collection methodologies, with capabilities for dynamic pruning and rearrangement of data tables and multiple export and analysis functions.