Database of protein disorder (DisProt)
Database of protein disorder (DisProt) provides manually curated annotations of intrinsically disordered proteins and regions from scientific literature to support research on protein disorder, structural biology, proteomics, and disease-related functional analysis.
Key Features:
- Manually curated annotations: Curations are extracted from scientific literature to provide high-quality, consistent annotations of intrinsically disordered proteins and regions.
- IDPO refactoring: The Intrinsically Disordered Proteins Ontology (IDPO) has been refactored to enable more structured and precise categorization of disorder-related information.
- Curation quality control: A reviewing mechanism and curator training were implemented to increase annotation quality and consistency.
- APICURON integration: Integration with APICURON records and acknowledges biocuration contributions.
- Data expansion: The annotated content increased by approximately 30% compared to the previous release.
- Standards and interoperability: Adherence to the Minimum Information About Disorder (MIADE) and collaborations with Gene Ontology (GO) and Evidence and Conclusion Ontology (ECO) improve interoperability.
- ELIXIR integration: Integration within the ELIXIR infrastructure supports resource interoperability and discoverability.
Scientific Applications:
- Protein disorder research: Enables compilation and analysis of experimentally validated intrinsically disordered regions for studies of disorder function and prevalence.
- Structural biology: Provides annotations that inform interpretation of structural heterogeneity and disorder in proteins.
- Proteomics: Supplies curated disorder annotations useful for proteomics analyses.
- Disease research: Supports investigation of the roles of intrinsically disordered regions in disease mechanisms.
Methodology:
Annotations are produced by manual curation from scientific literature; ontology refactoring (IDPO) and adherence to MIADE standardize annotations, and integrations with APICURON, GO, and ECO support interoperability.
Topics
Details
- License:
- CC-BY-NC-1.0
- Maturity:
- Mature
- Tool Type:
- api, web application
- Operating Systems:
- Linux, Windows, Mac
- Added:
- 3/29/2017
- Last Updated:
- 11/24/2024
Operations
Publications
Quaglia F, Mészáros B, Salladini E, Hatos A, Pancsa R, Chemes LB, Pajkos M, Lazar T, Peña-Díaz S, Santos J, Ács V, Farahi N, Fichó E, Aspromonte MC, Bassot C, Chasapi A, Davey NE, Davidović R, Dobson L, Elofsson A, Erdős G, Gaudet P, Giglio M, Glavina J, Iserte J, Iglesias V, Kálmán Z, Lambrughi M, Leonardi E, Longhi S, Macedo-Ribeiro S, Maiani E, Marchetti J, Marino-Buslje C, Mészáros A, Monzon AM, Minervini G, Nadendla S, Nilsson JF, Novotný M, Ouzounis CA, Palopoli N, Papaleo E, Pereira PJB, Pozzati G, Promponas VJ, Pujols J, Rocha ACS, Salas M, Sawicki LR, Schad E, Shenoy A, Szaniszló T, Tsirigos KD, Veljkovic N, Parisi G, Ventura S, Dosztányi Z, Tompa P, Tosatto SCE, Piovesan D. DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation. Nucleic Acids Research. 2021;50(D1):D480-D487. doi:10.1093/nar/gkab1082. PMID:34850135. PMCID:PMC8728214.