DoriC 12.0

DoriC 12.0 catalogs replication origins (oriCs) in bacterial and archaeal chromosomes and plasmids to support analysis of DNA replication initiation across complete and draft prokaryotic genomes.

Key Features:

• Extensive coverage: Includes over 200,000 bacterial oriC entries spanning more than 40 phyla and also contains oriCs from archaea and plasmids derived from both complete and draft genomes.
• Integration of novel phyla: Incorporates oriCs from newly identified bacterial phyla that were previously unexplored.
• Visualization and analysis: Provides enhanced visualization and analysis features for exploration and interpretation of oriC sequences and annotations.
• Aggregated genomic records: Aggregates oriC records across genomes to enable comparative analyses of replication origins.

Scientific Applications:

• Replication initiation research: Enables investigation of molecular mechanisms of DNA replication initiation by providing oriC sequences and annotations.
• Comparative genomics: Supports comparative genomics to identify evolutionary patterns and functional diversity of oriCs across bacterial species.
• Synthetic biology and genome engineering: Informs design of artificial genomes and plasmids by supplying oriC information relevant to replication control.
• Microbial genomics and bioinformatics: Facilitates studies requiring oriC localization and characterization across prokaryotic datasets.

Methodology:

No computational methods, algorithms, or file formats were specified in the provided description.