doRiNA

doRiNA maps interactions between RNA binding proteins (RBPs) and microRNAs (miRNAs) on mRNAs across transcriptomes to support analysis of post-transcriptional gene regulation.

Key Features:

• Database content: Houses genome-wide RBP and miRNA target predictions (Database of RBP and miRNA Target Predictions).
• Whole-transcriptome mapping: Maps RBP and miRNA interactions across the entire transcriptome using experimental data and computational predictions.
• Custom data uploads: Enables integration of user-supplied datasets with doRiNA's resources for combined analyses.
• Programmatic access: Provides a REST API for web-based queries and a Python API for local access.

Scientific Applications:

• Post-transcriptional regulatory network analysis: Identifies and maps RBP and miRNA interactions that regulate mRNA processing, stability, and translation.
• Disease mechanism investigation: Supports studies linking dysregulated RBP/miRNA interactions to disease pathogenesis.
• Therapeutic target prioritization: Assists in prioritizing RBP or miRNA targets within post-transcriptional regulatory networks.

Methodology:

Integrates experimental datasets with computational target predictions, supports custom data uploads, and exposes programmatic access via a REST API and a Python API.