Dr.VIS

Dr.VIS catalogs viral integration sites (VIS) associated with human diseases to support analysis of their genomic context and contributions to oncogenesis.

Key Features:

• Extensive Data Collection: Compiles approximately 600 natural VIS from five oncogenic viruses implicated in eleven different human diseases.
• Detailed Annotations: Provides characteristics of the associated malignant disease, specific chromosome region, genomic position, and viral-host junction sequence for about 200 sites.
• Focus on Oncogenesis: Highlights VIS located near oncogenes and common fragile sites to aid identification of potential oncogenes and study their role in cancer development.

Scientific Applications:

• Oncogene Identification: Enables pinpointing potential oncogenes by examining typical DNA features surrounding viral integration sites.
• Disease Prediction: Supports prediction of malignant disease development by providing data on how viral integrations may contribute to oncogenesis.
• Gene Therapy Safety Assessment: Provides information for assessing the risk of malignant transformation in gene therapy applications using viral vectors.

Methodology:

Systematically gathers and maintains data on human disease-related VIS, focusing on genomic context and sequence characteristics at integration sites to analyze viral integration preferences relative to host genome regions.