DRED

DRED compiles and curates information on genes related to repeat expansion diseases, serving as a central data resource for basic research and medical diagnosis of these disorders.

Key Features:

• Manually-curated known genes: DRED covers all 61 known genes related to repeat expansion diseases reported in PubMed and OMIM, with detailed repeat information for each gene.
• Predicted candidate genes: DRED includes 516 genes predicted to have potential to cause diseases via repeat expansion based on repeat composition, genetic variations, genomic features, and disease associations.
• External resource integration: DRED provides links to external resources such as NCBI and ClinVar.

Scientific Applications:

• Basic research on repeat expansion diseases: DRED serves as a central data resource for investigating genes and repeats associated with repeat expansion diseases such as fragile X syndrome, Huntington's disease, and spinocerebellar ataxia.
• Medical diagnosis: DRED supports repeat expansion disease-related medical diagnosis by consolidating scattered gene information and providing systematic predictions of potential disease-causing genes.

Methodology:

Candidate genes were predicted based on their repeat composition, genetic variations, genomic features, and disease associations.