DrosOMA

DrosOMA catalogs orthologues across Drosophila species and outgroup dipterans using the OMA Orthologous Matrix inference framework, enabling exploration, visualisation, and downloading of genus-wide orthology delineation results.

Key Features:

• Gene-view pages: Display comprehensive gene name and identifier cross-references together with available functional annotations and protein domain architectures.
• Orthologous group-view pages: Allow browsing of orthology predictions for groups of orthologues.
• Genome-view pages: Provide genome-level browsing of orthology data across species.
• Synteny visualisation tools: Enable visualisation of both local and global synteny conservation.
• Cross-reference integration: Incorporates comprehensive gene name and identifier cross-references from multiple sources.

Scientific Applications:

• Comparative genomics: Supports analyses to delineate gene evolutionary histories and characterise gene and gene family origins, trajectories, and dynamics.
• Speciation and duplication studies: Enables tracing of speciation, duplication, and loss events across Drosophila species.
• Functional annotation transfer: Facilitates transfer of gene functional information across species through orthology relationships.
• Synteny analysis: Supports investigation of local and global synteny conservation patterns.

Methodology:

DrosOMA uses the OMA Orthologous Matrix orthology inference approach to catalogue orthologues across a selected set of Drosophila species with high-quality annotated genomes and four outgroup dipterans.