DRscDB

DRscDB provides a curated cross-species single-cell RNA-seq resource that maps orthologous genes and literature-derived cell type marker expression across Drosophila, zebrafish, mouse, and human.

Key Features:

• Comprehensive Repository: Aggregates manually curated scRNA-seq datasets from Drosophila and analogous tissues in zebrafish, mouse, and human.
• Orthologous Gene Search: Enables querying orthologous genes across species to identify conserved or divergent expression patterns.
• Cell Type-Specific Expression Patterns: Stores literature-derived marker genes and preserves original published cell-type annotations and analyses for each dataset.

Scientific Applications:

• Comparative Genomics: Compare gene expression and orthology relationships across Drosophila, zebrafish, mouse, and human.
• Evolutionary Biology: Investigate conservation and divergence of gene expression across species.
• Developmental Biology and Cellular Differentiation: Study developmental processes and cell-type transitions by comparing marker gene expression across species.
• Disease Mechanism Research: Explore conserved or species-specific gene expression patterns relevant to disease mechanisms using model organism and human datasets.

Methodology:

Manual curation of Drosophila scRNA-seq studies, mapping datasets to analogous tissues in zebrafish, mouse, and human, and retention of literature-derived marker genes and original published analyses.