Drug-herb-interaction

Drug-herb-interaction compiles Medline-derived interaction data between the herbal supplements ginseng, ginkgo, and dong quai and Western medicines to support safety and efficacy assessments.

Key Features:

• Critically Reviewed Database: Compiles 135 sets of interaction data from Medline and yields 80 validated HDI monographs that meet predefined inclusion criteria.
• Reliability Assessment: Assigns per-interaction reliability levels labeled "likely", "possible", or "unevaluable".
• Search Functionality: Supports single and multiple query retrieval of interaction records.
• Data Ingestion: Supports batch updates of interaction data via Excel files.
• Interaction Outcomes: Reports that among 26 interactions classified as "likely", 50% are negative, ten may enhance drug effects, and three suggest possible beneficial outcomes.

Scientific Applications:

• Clinical decision support: Provides validated interaction evidence to inform clinician decision-making and patient counseling on co-administration of specified herbal supplements with Western medications.
• Research and public health: Supplies curated HDI monographs and quantified outcome data to support research, pharmacovigilance, and public health risk communication.

Methodology:

Uses Node.js for database management and Vue.js for the front end, and integrates critical literature reviews with per-interaction reliability assessments.