DrugCVar

DrugCVar provides evidence-based drug annotations for cancer-associated genetic variants to support interpretation for targeted therapy.

Key Features:

• Integration of Evidence Sources: Aggregates evidence from CIViC, OncoKB, CGI (The Cancer Genome Interpreter), and My Cancer Genome to compile clinical interpretations of cancer variants.
• Manually Curated Data: Contains 7,830 clinically relevant evidences curated from the literature and classified into ten evidence tiers.
• Batch Annotation Module: Supports batch annotation of user-provided genetic variants in various formats for high-throughput analyses.
• Detailed Variant Information: Reports mutation function, genomic and protein location, and mutation statistics across tumor types for queried genes and variants.
• Search and Retrieval Functions: Provides mechanisms to retrieve specific variant–drug targeting evidence and associated annotations.

Scientific Applications:

• Precision oncology decision support: Enables interpretation of therapeutic options for cancer-related genetic variants using evidence-based annotations.
• Research on mutation–drug interactions: Facilitates exploration of relationships between specific variants and drug responses across datasets.
• Variant impact analysis across cancers: Supports comparative analysis of mutation frequencies and functional consequences across tumor types.

Methodology:

Data integration from CIViC, OncoKB, CGI, and My Cancer Genome combined with manual literature curation, and classification of evidences into ten tiers.