DrugVirus
DrugVirus provides a curated database and analytical resource for discovery, characterization, and prioritization of safe-in-man broad-spectrum antiviral agents (BSAAs) to support pre-clinical and clinical research.
Key Features:
- Database Access: DrugVirus compiles structured information on 120 safe-in-man broad-spectrum antiviral agents, including human safety profiles and reported antiviral spectra.
- Pre-clinical and Clinical Support: DrugVirus supports identification and prioritization of candidate BSAAs, expansion of indications, and selection of effective drug combinations for treating viral infections and co-infections.
- Mechanistic and Safety Insights: DrugVirus synthesizes mechanistic data and clinical safety information to inform therapeutic potential and compound selection.
Scientific Applications:
- Public Health Preparedness: DrugVirus informs development of antiviral therapies and preparedness strategies against emerging and re-emerging viral pathogens by aggregating BSAA data.
- Drug Combination Design and Trial Planning: DrugVirus aids identification and prioritization of drug combinations and supports strategic planning of pre-clinical and clinical studies.
- Virology and Pharmacology Research: DrugVirus enables exploration and comparative analysis of novel broad-spectrum antiviral compounds across virology, pharmacology, and public health domains.
Methodology:
DrugVirus synthesizes existing research and clinical data on broad-spectrum antivirals to derive insights into mechanisms of action, safety profiles, and therapeutic potential.
Topics
Collections
Details
- Tool Type:
- web application
- Added:
- 1/14/2020
- Last Updated:
- 12/9/2020
Operations
Publications
Andersen PI, Ianevski A, Lysvand H, Vitkauskiene A, Oksenych V, Bjoras M, Telling K, Lutsar I, Dumpis U, Irie Y, Tenson T, Kantele A, Kainov DE. Discovery and Development of Safe-in-Man Broad-Spectrum Antiviral Agents. Unknown Journal. 2019. doi:10.20944/preprints201910.0144.v2.
Andersen PI, Ianevski A, Lysvand H, Vitkauskiene A, Oksenych V, Bjoras M, Telling K, Lutsar I, Dumpis U, Irie Y, Tenson T, Kantele A, Kainov DE. Discovery and Development of Safe-in-Man Broad-Spectrum Antiviral Agents. Unknown Journal. 2019. doi:10.20944/preprints201910.0144.v1.
Andersen PI, Ianevski A, Lysvand H, Vitkauskiene A, Oksenych V, Bjørås M, Telling K, Lutsar I, Dumpis U, Irie Y, Tenson T, Kantele A, Kainov DE. Discovery and development of safe-in-man broad-spectrum antiviral agents. International Journal of Infectious Diseases. 2020;93:268-276. doi:10.1016/j.ijid.2020.02.018. PMID:32081774. PMCID:PMC7128205.
Andersen PI, Ianevski A, Lysvand H, Vitkauskiene A, Oksenych V, Bjoras M, Telling K, Lutsar I, Dumpis U, Irie Y, Tenson T, Kantele A, Kainov DE. Discovery and Development of Safe-in-Man Broad-Spectrum Antiviral Agents. Unknown Journal. 2020. doi:10.20944/preprints201910.0144.v6.
Andersen PI, Ianevski A, Lysvand H, Vitkauskiene A, Oksenych V, Bjoras M, Telling K, Lutsar I, Dumpis U, Irie Y, Tenson T, Kantele A, Kainov DE. Discovery and Development of Safe-in-Man Broad-Spectrum Antiviral Agents. Unknown Journal. 2020. doi:10.20944/preprints201910.0144.v5.
Andersen PI, Ianevski A, Lysvand H, Vitkauskiene A, Oksenych V, Bjoras M, Telling K, Lutsar I, Dumpis U, Irie Y, Tenson T, Kantele A, Kainov DE. Discovery and Development of Safe-in-Man Broad-Spectrum Antiviral Agents. Unknown Journal. 2020. doi:10.20944/preprints201910.0144.v4.
Andersen PI, Ianevski A, Lysvand H, Vitkauskiene A, Oksenych V, Bjoras M, Telling K, Lutsar I, Dumpis U, Irie Y, Tenson T, Kantele A, Kainov DE. Discovery and Development of Safe-in-Man Broad-Spectrum Antiviral Agents. Unknown Journal. 2019. doi:10.20944/preprints201910.0144.v3.