DSCI

DSCI curates synthetic biology components for innate immunity and cell engineering to guide gene circuit design and modification.

Key Features:

• Curated Component Collection: DSCI incorporates 1240 independent components and more than 4000 specific entries contextually annotated from public literature with experimental verification.
• Visualized Signaling Motifs: Components are presented as visualized signaling motifs that participate in innate immunity with interactive navigation.
• Comprehensive Annotations: Data includes components of pathways, relationships between regulators, signal motifs based on regulatory cascades, and loop graphs, all comprehensively annotated to help guide modifications to gene circuits.

Scientific Applications:

• Innate Immune Signaling Circuit Design: DSCI provides insights and strategies for innate immune signaling circuit design in biosynthesis.
• Gene Circuit Construction Guidance: DSCI offers guidance for gene circuits construction to make decisions of cell engineering based on innate immunity.
• Medical Synthetic Biology Strategy Development: DSCI serves as a tool to offer modification or generation strategies for medical synthetic biology.

Methodology:

Components were curated from public literature with experimental verification and annotated contextually; data integration includes pathway components, regulator relationships, regulatory cascade-based signal motifs, and loop graphs.