DSMZCellDive

DSMZCellDive provides centralized access to authenticated high-throughput data on human and animal cell lines for genomic and gene expression analyses.

Key Features:

• Authenticated data access: Aggregates contaminant-free cell line data sourced directly from the DSMZ biorepository and certified biorepositories to support reproducibility.
• Comprehensive data types: Includes RNA-seq transcriptome data and STR (short tandem repeat) profiles for genomic and expression studies.
• Expanded STR panel: Provides an STR panel with 17 loci enabling measurement of genomic loss of heterozygosity (LOH) and cell line identity assessment.
• Scalability for data integration: Supports future integration of additional meta and high-throughput datasets.

Scientific Applications:

• B-cell differentiation analysis: Enables examination of B-cell differentiation markers using transcriptome data.
• Homeo-oncogene expression studies: Supports investigation of homeo-oncogene expression patterns in cell lines via RNA-seq data.
• Genomic stability assessment: Allows detection and analysis of genomic loss of heterozygosity and genetic stability using the 17-locus STR panel.

Methodology:

DSMZCellDive centralizes and shares high-throughput datasets by aggregating RNA-seq transcriptome data and STR profiles directly from the DSMZ biorepository and other certified sources.