DTU-DADS-Aqua

DTU-DADS-Aqua simulates waterborne transmission dynamics of infectious pathogens in marine aquaculture to evaluate outbreak progression and the impact of surveillance and control measures.

Key Features:

• Stochastic spatiotemporal hybrid model: Integrates stochastic spatiotemporal dynamics to represent temporal and spatial variability in pathogen spread.
• Compartmental model: Simulates within-net-pen infection dynamics using compartmental approaches.
• Agent-based model: Represents interactions and transmission between net-pens and farm sites with agent-based modeling incorporating farm-site hydroconnectivity informed by seaway distances.
• Simulation of transmission and control processes: Implements transmission processes and control measures including surveillance, detection, and depopulation strategies.
• Scenario analysis: Enables exploration of "what-if" scenarios by varying daily surveillance intensity, depopulation capacity, and triggers based on increased animal mortality for diagnostic testing.

Scientific Applications:

• ISAv in Atlantic salmon (New Brunswick and Maine): Simulates infectious salmon anaemia virus (ISAv) spread among farmed Atlantic salmon across transboundary regions of New Brunswick, Canada, and Maine, United States.
• Evaluation of control strategies: Assesses the effectiveness of enhanced disease detection, increased surveillance visits, and depopulation measures on outbreak outcomes.
• Adaptation to other aquatic pathogens: Can be applied to other infectious diseases in aquatic environments by incorporating alternative transmission and control dynamics specific to different pathogens or aquaculture systems.

Methodology:

Uses a stochastic spatiotemporal hybrid modeling framework combining compartmental models for within-net-pen spread and agent-based models for between-site transmission; incorporates farm-site hydroconnectivity using seaway distances; simulates surveillance, detection, and depopulation control measures.