EasyReg

EasyReg performs symmetric multi-modality registration of brain magnetic resonance imaging (MRI) to enable accurate alignment across modalities and resolutions.

Key Features:

• Symmetric Registration: Ensures symmetry in the registration process for unbiased image alignment.
• Diffeomorphic Transformations: Produces diffeomorphic transformations that are invertible and smooth to preserve anatomical topology.
• Modality and Resolution Agnosticism: Operates independently of MRI modality and resolution to handle diverse imaging scenarios.
• Affine and Nonlinear Compatibility: Supports both affine and nonlinear registration models for comprehensive alignment.
• Domain Randomization: Incorporates domain randomization to enhance robustness to modality and resolution changes.
• Performance: Empirical results show comparable performance to classical methods for 1 mm isotropic single-modality registration and superior accuracy across different modalities and resolutions.

Scientific Applications:

• Multi-modality Alignment: Aligning different MRI modalities for integrated analysis.
• Longitudinal Analysis: Measuring anatomical changes over time in longitudinal studies.
• Template Mapping: Mapping individual scans to a standardized template for group analyses.
• Registration-based Segmentation: Facilitating segmentation by transferring labels or priors via registration.

Methodology:

Leverages domain randomization and combines classical registration methods with modern deep learning techniques.