eccDB

eccDB provides an integrative repository of extrachromosomal circular DNA (eccDNA) data across multiple species to support analysis of their regulatory and epigenetic roles.

Key Features:

• Multispecies Integration: Consolidates eccDNA information from multiple species to enable comparative and evolutionary analyses.
• Regulatory and Epigenetic Annotations: Provides detailed regulatory and epigenetic data on eccDNAs with emphasis on their transcriptional regulatory potential.
• Identification Tools: Includes tools for identifying eccDNAs from unknown DNA sequences to support functional characterization.
• Chromatin Contact Analysis: Analyzes chromatin contacts mediated by eccDNAs, including intrachromosomal and interchromosomal interactions, to inform functional predictions.
• Evolutionary Relationship Assessment: Supports assessment of evolutionary relationships among eccDNAs across species.

Scientific Applications:

• Molecular mechanism studies: Enables investigation of molecular mechanisms underlying eccDNA function.
• Genomics and epigenetics research: Supports studies in genomics and epigenetics to elucidate eccDNA contributions to gene regulation and chromatin architecture.
• Evolutionary biology: Facilitates comparative and evolutionary analyses of eccDNAs across species.

Methodology:

Identification of eccDNAs from unknown DNA sequences; analysis of chromatin contacts mediated by eccDNA, including intrachromosomal and interchromosomal interactions, to predict transcriptional regulatory functions; comparative analyses across species to assess evolutionary relationships.