EffectiveDB

EffectiveDB predicts bacterial protein secretion systems and their putative secreted proteins (effectors) to support analyses of bacterial–host interactions.

Key Features:

• Dual prediction strategies: combines eukaryotic-like protein domain detection and signal peptide recognition to identify proteins likely secreted by bacterial secretion systems.
• Precalculated genome-wide predictions: contains precalculated predictions for entire bacterial genomes enabling large-scale analyses of secretion systems and effectors.
• Sequence-based prediction tools: supports prediction on user-provided protein sequences to identify candidate secreted proteins and effectors.

Scientific Applications:

• Virulence mechanism analysis: identification of secreted proteins and effectors to elucidate bacterial pathogenicity mechanisms.
• Symbiosis research: prediction of effector proteins involved in bacterial symbiotic interactions with hosts.
• Genomic discovery of secretion systems: support for genome-scale identification of novel secretion systems and associated effectors.

Methodology:

Integrates eukaryotic-like protein domain identification with signal peptide analysis and provides precalculated genome-wide predictions.