EmAtlas

EmAtlas provides a spatiotemporal multi-omics compendium and analytical resource for investigating molecular events in mouse and human embryogenesis.

Key Features:

• Extensive Multi-Omics Data Collection: Aggregates datasets for gene expression, chromatin accessibility, DNA methylation, nucleosome occupancy, histone modifications, and transcription factors.
• Spatiotemporal Developmental Coverage: Represents developmental stages including gametogenesis, preimplantation, fetal development, and neonatal phases in mouse and human models.
• Multi-Scale Analytical Tools: Provides analyses at tissue, cell, genome, gene, and protein levels to characterize signatures of mammalian embryogenesis.
• EmRanger Annotations: Includes the EmRanger module to supply extensive developmental biology annotations for contextual interpretation.

Scientific Applications:

• Stem Cell Differentiation: Supports analysis of molecular signatures and trajectories underlying stem cell differentiation during embryogenesis.
• Congenital Disease Research: Enables investigation of molecular underpinnings of human congenital diseases by mapping developmental regulatory states.
• Assisted Reproductive Technologies: Informs studies relevant to assisted reproductive technologies by characterizing early developmental stages.

Methodology:

Aggregates multi-omics datasets and applies analytical tools operating at tissue, cell, genome, gene, and protein scales, and includes the EmRanger annotation module.