EMDataBank.org

EMDataBank.org aggregates public cryo-electron microscopy (cryo-EM) maps, atomic models, and associated metadata by integrating the Electron Microscopy Data Bank (EMDB) and the Protein Data Bank (PDB) through collaboration among PDBe, RCSB, and NCMI to support structural biology research.

Key Features:

• Deposition and retrieval: Accepts and provides access to deposited cryo-EM maps, atomic models, and associated metadata.
• Integrated archives: Unifies data from the Electron Microscopy Data Bank (EMDB) and the Protein Data Bank (PDB).
• Data types stored: Stores cryo-EM reconstruction maps and atomic models for macromolecules and macromolecular complexes.
• Metadata preservation: Retains experimental annotations and metadata linked to cryo-EM maps and models.
• Support for reconstructions: Hosts data produced by cryo-electron microscopy reconstruction methods.

Scientific Applications:

• Structural biology: Enables determination and validation of macromolecular structures from cryo-EM maps and models.
• Macromolecular assembly analysis: Supports study of large macromolecules and macromolecular complexes that are challenging for other techniques.
• Structure-guided drug design: Provides structural data used for rational drug-design and ligand interaction analysis.
• Biotechnology and molecular biology: Facilitates engineering and functional interpretation of macromolecular assemblies.

Methodology:

Aggregates and integrates data from the Electron Microscopy Data Bank (EMDB) and the Protein Data Bank (PDB), storing cryo-electron microscopy reconstruction maps, atomic models, and associated metadata.