EMICSS

EMICSS automatically updates cross-references for EMDB entries with over 20 external resources, adding value annotations that connect three-dimensional electron microscopy data to related biological, functional, and structural data resources.

Key Features:

• Automated Cross-Referencing: EMICSS automatically updates cross-references with over 20 external resources, including UniProt, AlphaFold DB, PubMed, Complex Portal, and Gene Ontology.
• Multiple Output Formats: Annotations are accessible in multiple formats for every EMDB entry and its linked resources.
• Programmatic Access: Annotations are available programmatically via the EMDB application programming interface.
• EMDB Website Integration: EMICSS annotations are used on EMDB entry pages, statistics, and in the search system.

Scientific Applications:

• 3DEM Data Annotation: EMICSS provides comprehensive annotations for three-dimensional electron microscopy data in EMDB, addressing the limitation of sparse depositor-provided information.
• Structural Biology Integration: EMICSS connects EMDB entries to protein sequence databases, predicted structure databases, literature databases, macromolecular complex databases, and functional annotation resources.

Methodology:

EMICSS is implemented in Python and operates as an independent system from EMDB.