Ensembl Genomes Fungi sequence search

Ensembl Genomes Fungi sequence search searches fungal genomic sequences in Ensembl to enable sequence comparison and gene-structure annotation using Exonerate while providing access to genome assemblies, annotations, regulatory datasets, the Variant Effect Predictor (VEP), and the Ensembl REST API.

Key Features:

• Integration with Ensembl Fungi: Provides access to Ensembl Fungi genome assemblies, annotations, and species-specific genomic data.
• Utilization of Exonerate: Employs Exonerate for sequence alignment, homolog detection, and gene-structure prediction.
• Access to Comprehensive Data: Exposes updated genome assemblies, comprehensive annotations, and regulatory datasets across multiple fungal species.
• Enhanced Analytical Tools: Supports the Variant Effect Predictor (VEP) and the Ensembl REST API for variant annotation and programmatic data retrieval.
• Regulatory Data Access via BioMart: Enables retrieval of regulatory datasets through BioMart for studies of gene regulation.

Scientific Applications:

• Genomic Research: Facilitates exploration of fungal genetic diversity, genome structure, and species-specific adaptations.
• Functional Annotation: Assists annotation of genes and regulatory elements within fungal genomes.
• Comparative Genomics: Enables comparative analyses between fungal species to identify conserved functions and evolutionary relationships.
• Pathogen Research: Supports genomic investigations of pathogenic fungi to inform studies of virulence mechanisms and potential targets.

Methodology:

Sequence analysis uses Exonerate integrated with Ensembl's data infrastructure, leveraging updated genome assemblies, annotations, regulatory datasets, and supporting VEP and the Ensembl REST API for annotation and data access.