Ensembl Genomes Metazoa sequence search

Ensembl Genomes Metazoa sequence search performs sequence searches and alignments of Metazoa genomic sequences using Exonerate to support comparative genomics and genome annotation within the Ensembl Metazoa database.

Key Features:

• Integration with Exonerate: Utilizes Exonerate to perform detailed sequence alignments and comparisons within Metazoa sequences.
• Access to extensive genomic data: Provides sequence data for 87 species, including assemblies and annotations for human, mouse, zebrafish, and rat.
• Support for latest genome assemblies: Focuses on current genome assemblies and includes updates for previous assemblies such as GRCh37.

Scientific Applications:

• Genome annotation and analysis: Supports annotation and analysis of metazoan genomes for evolutionary biology, genetics, and molecular biology studies.
• Comparative genomics: Enables sequence-level comparisons across diverse metazoan species to investigate genomic evolution and function.
• Model organism research: Provides genomic sequence resources relevant to developmental biology and disease-modeling research in key model organisms.

Methodology:

Performs sequence searches and precise alignments using Exonerate within the Ensembl Metazoa database and integrates results with Variant Effect Predictor (VEP) and BioMart.