ENZYME - Enzyme nomenclature database

ENZYME catalogs enzyme nomenclature and assigns Enzyme Commission (EC) numbers to classify and characterize enzymes according to recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) to enable standardized identification in biochemical research.

Key Features:

• Enzyme nomenclature and EC numbers: Provides standardized Enzyme Commission (EC) numbers for characterized enzymes.
• IUBMB-based classification: Classifies enzymes according to recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB).
• Data scope: Contains information on 3,705 enzymes.
• Functional and pathway annotations: Includes information on enzyme functions, interactions, and roles in biochemical pathways.
• Support for metabolic databases: Supplies structured enzyme nomenclature data used in the development of metabolic databases.
• Structured nomenclature approach: Maintains consistent classification to support standardized identification and communication in biochemical research.

Scientific Applications:

• Metabolic database development: Provides standardized enzyme identifiers and classifications for integrating enzyme data into metabolic databases.
• Bioinformatics and systems biology: Enables incorporation of enzyme nomenclature into bioinformatics analyses and systems-level models.
• Enzymology research: Supports characterization and comparison of enzyme activities and classifications.
• Metabolic engineering and drug discovery: Supplies enzyme classification and functional context relevant to pathway modification and target identification.
• Pathway modeling and analysis: Facilitates mapping of enzymes to biochemical pathways for computational modeling and analysis.

Methodology:

Assignment of Enzyme Commission (EC) numbers to characterized enzymes according to recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and provision of structured enzyme data for integration into bioinformatics frameworks.