epico-data-analysis-portal

epico-data-analysis-portal provides a framework (EPICO) for creating comparative epigenomic data portals and enables analysis of large epigenomic datasets, including comparative analysis of epigenomes across hematopoietic cell types.

Key Features:

• Reference framework: Provides a reference framework for constructing comparative epigenomic data portals that integrate and compare epigenomic datasets.
• Interactive exploration: Enables examination of genomic regions, genes, and pathways in the context of hematopoietic lineage differentiation.
• Comparative analysis: Implements comparative analysis based on basic analysis pipelines by identifying the positions of epigenetic features across different cell types.
• BLUEPRINT Data Analysis Portal (BDAP) implementation: BDAP is the inaugural implementation focusing on comparative analysis of epigenomes across hematopoietic cell types.

Scientific Applications:

• Comparative epigenomics of hematopoiesis: Comparative analysis of epigenomes across hematopoietic cell types to reveal cell-type-specific epigenetic patterns.
• Hematopoietic differentiation studies: Analysis of genomic regions, genes, and pathways to investigate hematopoietic lineage differentiation.
• Epigenetics and disease: Assessment of how epigenetic modifications relate to cellular processes and disease states.

Methodology:

Uses basic analysis pipelines to identify positions of epigenetic features and performs comparative analysis of epigenomes across hematopoietic cell types.