EpiFactors

EpiFactors catalogs functional information on human and mouse epigenetic regulators, including proteins (histones and protamines) and long non-coding RNAs (lncRNAs), and provides expression data to support studies of gene expression regulation and genome stability mediated by covalent DNA and histone modifications.

Key Features:

• Curated Information: Manually curated entries cover 815 epigenetic proteins, including 95 histones and protamines, and include annotations for other epigenetic regulators and lncRNAs in human and mouse.
• Expression Data: Expression values are provided for 789 genes across 458 human primary cell samples (≈200 cell types), 255 cancer cell lines (≈150 cancer subtypes), and 134 human postmortem tissues.
• Protein Complexes: Annotations include 69 protein complexes involved in epigenetic regulation.
• Data Source: Expression values are derived from Cap Analysis of Gene Expression (CAGE) data produced by the FANTOM5 consortium.

Scientific Applications:

• Gene regulation studies: Support investigation of how epigenetic regulators and their covalent DNA/histone modifications control gene expression and genome stability.
• Cancer and disease research: Enable analysis of epigenetic factor expression across cancer cell lines and tissues to study roles in pathological states.
• Target identification: Facilitate linking epigenetic regulators to expression patterns for identification of potential therapeutic targets in pharmacological and clinical research.

Methodology:

Expression values were derived using Cap Analysis of Gene Expression (CAGE) data generated by the FANTOM5 consortium.