EpiToolKit

EpiToolKit provides immunoinformatics analyses for MHC genotyping, epitope and neo-epitope prediction, epitope selection and assembly to support vaccine design and cancer immunotherapy research.

Key Features:

• MHC genotyping: Performs MHC genotyping to characterize alleles that influence antigen presentation.
• Epitope prediction: Predicts epitopes using integrated immunoinformatics tools.
• Neo-epitope prediction: Predicts neo-epitopes to identify tumor-specific antigenic targets.
• Epitope selection: Supports selection of epitopes tailored for vaccine design.
• Epitope assembly: Assembles selected epitopes into candidate constructs.
• Workflow composition (version 2.0): Enables combination of different tools into complex computational workflows.
• Integrated immunoinformatics suite: Integrates an extensive suite of immunoinformatics tools covering multiple stages of vaccine research.

Scientific Applications:

• Vaccine design: Supports vaccine design by predicting and selecting epitopes critical for eliciting immune responses.
• Population immunogenetics: Uses MHC genotyping to assess how genetic backgrounds influence immune responses across populations.
• Cancer immunotherapy: Identifies neo-epitope candidates as potential targets for personalized cancer immunotherapy.

Methodology:

Computational methods include MHC genotyping, epitope and neo-epitope prediction, epitope selection and assembly, and combination of immunoinformatics tools into complex workflows.