ePlant

ePlant visualizes and integrates multi-scale biological data to enable exploration of DNA sequences, single nucleotide polymorphisms (SNPs), molecular and protein structures, protein-protein interactions, and gene expression patterns in model organisms such as Arabidopsis thaliana.


Key Features:

  • Multi-Scale Data Integration: Integrates data across scales including DNA sequences, natural variation (polymorphisms), molecular structures, protein-protein interactions, and gene expression patterns.
  • Interactive Three-Dimensional Models: Provides interactive three-dimensional visualizations for multi-scale representation of biological data.
  • Sequence Conservation Explorer: Displays homology relationships and single nucleotide polymorphism (SNP) data to examine sequence conservation.
  • Protein Structure Model Explorer: Represents experimentally determined and theoretical protein structures and covers over 70% of the Arabidopsis thaliana proteome.
  • Molecular Interaction Network Explorer: Visualizes molecular interactions and protein-protein interaction networks.
  • Gene Product Subcellular Localization Explorer: Maps gene product localization within cellular compartments.
  • Gene Expression Pattern Explorer: Visualizes spatial and temporal gene expression patterns across conditions or developmental stages.
  • Organism Scope: Applied to Arabidopsis thaliana and extendable to other model organisms.
  • 3D Data Display Initiative (3DDI): Participates in the 3D Data Display Initiative (3DDI) to support development of three-dimensional biological data displays.

Scientific Applications:

  • Genetic variation analysis: Investigate effects of genetic variation and SNPs on protein function and structure.
  • Molecular interaction and pathway analysis: Study molecular interactions, protein-protein interactions, and cellular pathways.
  • Gene expression analysis: Analyze spatial and temporal gene expression patterns across conditions or developmental stages.

Methodology:

No computational methods, algorithms, or specific processing steps were specified in the provided description.

Topics

Collections

Details

License:
CC-BY-2.5
Tool Type:
web application
Operating Systems:
Linux, Windows, Mac
Programming Languages:
JavaScript
Added:
3/30/2017
Last Updated:
1/29/2019

Operations

Publications

Fucile G, Di Biase D, Nahal H, La G, Khodabandeh S, Chen Y, Easley K, Christendat D, Kelley L, Provart NJ. ePlant and the 3D Data Display Initiative: Integrative Systems Biology on the World Wide Web. PLoS ONE. 2011;6(1):e15237. doi:10.1371/journal.pone.0015237. PMID:21249219. PMCID:PMC3018417.

Documentation