ERGO Genome Analysis and Discovery System

ERGO Genome Analysis and Discovery System integrates diverse biological data to enable comprehensive genomic analysis and discovery of gene functions and cellular pathways.

Key Features:

• Data Integration: Integrates genomics, biochemistry, high-throughput expression profiling, genetics, and peer-reviewed literature for consolidated analysis.
• Comparative Genomics: Performs comparative genomics to assign gene functions and detect conserved features across genomes.
• Pattern-Based Analysis: Applies pattern-based methodologies to analyze genomic data within biological contexts.
• Visualization of Genomic Context: Visualizes genes relative to regulation, expression profiling, phylogenetic clusters, fusion events, networked cellular pathways, and chromosomal neighborhoods of functionally related genes.
• Curated Integrated Genome and Pathway Database: Maintains an extensively curated database integrating 500 genomes and a comprehensive collection of reconstructed cellular pathways across all domains of life.
• Gene and Pathway Discovery: Identifies previously unknown or mischaracterized genes, cryptic pathways, and gene products through integrated and comparative analyses.

Scientific Applications:

• Functional Gene Assignment: Assigns functions to genes by integrating them into known and novel pathways.
• Pathway Reconstruction: Reconstructs cellular pathways spanning all domains of life to support systems biology research.
• Genomic Discovery: Detects unknown or mischaracterized genetic elements and gene products through comparative and pattern-based analyses.

Methodology:

Integrates genomics, biochemistry, high-throughput expression profiling, genetics, and literature into an extensively curated database; employs comparative genomics and pattern-based methodologies to analyze genomic data and reconstruct cellular pathways; and visualizes genes in relation to regulation, expression profiling, phylogenetic clusters, fusion events, networked cellular pathways, and chromosomal neighborhoods to facilitate identification of unknown or mischaracterized genes and pathways.