ET Report Maker

ET Report Maker generates PDF reports that integrate evolutionary trace analyses with sequence, structure, and annotation data to identify functionally significant amino acid residues.

Key Features:

• Input Requirements: Accepts a Protein Data Bank (PDB) identifier or a UniProt accession number as input.
• Data Integration: Aggregates data from databases concerning protein sequences, structures, and basic annotations.
• Real-valued Evolutionary Trace: Applies the real-valued evolutionary trace method to infer residue-specific evolutionary behavior and conservation patterns.
• Multiple Sequence Analysis: Performs real-time multiple sequence analyses as part of the evolutionary inference.
• Structural Mapping: Superimposes evolutionary trace inferences onto existing structural and sequence data to localize predicted functional sites.
• Report Generation: Produces human-readable PDF documents that include original data for verification and reproduction.

Scientific Applications:

• Functional Site Prediction: Identifies protein regions and amino acid residues likely to be functionally significant based on evolutionary trace scores.
• Novel Protein Functional Inference: Provides evidence to support hypotheses about functional domains and active sites in novel proteins.

Methodology:

Aggregates sequences, structures, and annotations from databases; performs real-time multiple sequence analyses; applies the real-valued evolutionary trace method; and superimposes trace inferences onto structural and sequence data to generate PDF reports containing original data.