ETph

ETph catalogs enhancer elements and their target genes across pig and human genomes to support comparative regulatory genomics.

Key Features:

• Integration of Genomic Data: Consolidates information on human enhancers and pig putative enhancers, identifying 25,182 potential enhancer sequences in the pig genome by leveraging human genome homology.
• High-Confidence Enhancer Dataset: Provides a curated subset of 6,232 high-confidence pig enhancers.
• Comprehensive Annotations: Associates enhancers with target genes, pig quantitative trait loci (QTL) terms, human diseases, Gene Ontology (GO) terms, and KEGG pathways.
• Analytical Tools: Includes web-based analytical tools for visualizing networks and topology graphs that depict relationships among pig putative enhancers, target genes, pig QTL traits, and human diseases.

Scientific Applications:

• Comparative genomics and translational research: Link enhancer-target relationships between pig and human to inform cross-species regulatory and translational studies.
• Trait and disease investigation: Investigate genetic underpinnings of pig traits and their relevance to human health by connecting pig enhancers and pig QTL traits to human disease annotations.
• Cross-species enhancer annotation: Annotate human enhancers using pig genomic homology to uncover potential disease associations.
• Regulatory function analysis: Explore the functional roles of enhancers in gene regulation across pig and human genomes.

Methodology:

Enhancer sequences in pigs were identified by leveraging homologous sequence information from the human genome.