EView

EView simulates three-dimensional electric field distributions for electroporation-based treatments using needle-shaped electrodes to support planning and analysis.

Key Features:

• 3D Electric Field Simulation: Simulates electric field distribution in three dimensions specific to electroporation-based treatments.
• Needle-shaped Electrode Modeling: Models needle-shaped electrodes with variable positions and orientations to estimate their influence on field distribution.
• Integration with Medical Imaging: Overlays simulated electric field distributions onto 3D medical images.
• Finite Element Method (FEM) Simulation: Employs the finite element method to solve electric field distribution within a 3D volume.
• Homogeneous Tissue Modeling: Represents tissue as homogeneous with uniform properties across healthy and pathological regions.
• Non-linear Conductivity Modeling: Accounts for the non-linear dependence of tissue conductivity on electric field strength due to electroporation.
• Validation: Validated against a state-of-the-art finite element solver with Dice coefficient = 98.3 ± 0.4%.
• Computation Time Benchmarks: Simple two-electrode configurations complete in under two minutes, while scenarios with up to six electrodes can take up to forty minutes.

Scientific Applications:

• Preoperative Planning: Estimate electric field distributions to inform determination of effective treatment volumes for electroporation procedures.
• Research and Development: Compare alternative electrode configurations and assess their effects on electric field distributions for experimental design.
• Education and Training: Demonstrate principles of electroporation and the effects of electrode placement on electric fields.

Methodology:

Finite element method (FEM) solves 3D electric field distributions using a homogeneous tissue model with non-linear conductivity dependent on electric field strength; simulated fields are overlaid on 3D medical images and the model was validated against a state-of-the-art FEM solver (Dice = 98.3 ± 0.4%).