EVLncRNAs

EVLncRNAs provides a manually curated database of experimentally validated long noncoding RNAs (lncRNAs), integrating sequence, structural, functional, and phenotypic information to support studies of lncRNA function and disease associations.

Key Features:

• Comprehensive data collection: EVLncRNAs 2.0 incorporates literature up to May 15, 2020 with extensive manual curation and reports increases of annotated lncRNAs (260%), associated diseases (320%), lncRNA–disease associations (484%), and interaction records (537%).
• Diverse categories: The database includes subclassifications such as 8 lncRNA structures, 33 exosomal lncRNAs, 188 circular RNAs, and 1,079 drug-resistant/chemoresistant/stress-resistant lncRNAs.
• Quality assurance: All records were verified against known retracted and fake articles to enhance data reliability.
• Integration with existing resources: EVLncRNAs integrates entries from lncRNAdb, LncRANDisease, Lnc2Cancer, and PLNIncRBase, comprising 1,543 lncRNAs from 77 species, of which 74% are new or partially new relative to those databases.

Scientific Applications:

• Functional characterization: Provides experimentally validated lncRNA entries to support studies of lncRNA roles in biological processes.
• Disease association studies: Enables investigation of lncRNA involvement in disease mechanisms through curated lncRNA–disease associations.
• Therapeutic response and resistance research: Supports analysis of lncRNAs linked to therapeutic responses, drug resistance, chemoresistance, and stress resistance.
• Gene regulation and molecular interaction studies: Supplies curated sequence, structure, and interaction data to study gene regulation and molecular interactions involving lncRNAs.
• Precision medicine research: Facilitates exploration of experimentally validated lncRNAs for potential applications in precision medicine.

Methodology:

Manual curation of peer-reviewed literature was used to extract and integrate sequence, structural, functional, and phenotypic information for experimentally validated lncRNAs.