EWAS Catalog

EWAS Catalog curates and aggregates epigenome-wide association study (EWAS) results linking DNA methylation at CpG sites to traits and exposures.

Key Features:

• Scope: Contains 1,737,746 associations derived from 2,686 distinct EWAS.
• Publication-derived data: Includes 1,345,398 associations sourced from 342 peer‑reviewed publications.
• Summary statistics: Provides summary statistics for 392,348 associations from 427 EWAS conducted on datasets such as ALSPAC and GEO.
• Measurement coverage: Captures DNA methylation measurements at thousands to millions of CpG sites.
• Significance filtering: Catalogs CpG–trait associations filtered at p<1x10^-4.
• Study types: Aggregates results from population‑based cohorts and case‑control studies.

Scientific Applications:

• Association discovery: Identify CpG–trait and CpG–exposure associations across the genome.
• Disease mechanism exploration: Investigate molecular mechanisms underlying diseases via methylation–trait associations.
• Epigenetic epidemiology: Compare EWAS results across cohorts and study designs to assess methylation signatures of traits and exposures.

Methodology:

Aggregates curated CpG–trait associations and summary statistics extracted from peer‑reviewed publications and EWAS datasets (e.g., ALSPAC, GEO) and retains associations meeting a p<1x10^-4 threshold.