EWAS

EWAS provides integrated data and analytical tools for epigenome-wide association studies, aggregating DNA methylation associations, normalized methylation array data, and enrichment, annotation, and network-analysis functionalities.

Key Features:

• Platform components: EWAS integrates three core components: the EWAS Atlas, EWAS Data Hub, and the EWAS Toolkit.
• Aggregated EWAS associations: The resource includes 617,018 high-quality EWAS associations curated from 910 publications and covering 51 phenotypes, 275 diseases, and 104 environmental factors.
• Comprehensive DNA methylation data: The platform provides well-normalized DNA methylation array data and associated metadata for 115,852 samples encompassing 707 tissues, 218 cell lines, and links to 528 diseases.
• Analytical toolkit: The EWAS Toolkit supports enrichment analysis, annotation, and construction and visualization of knowledge networks.

Scientific Applications:

• Epigenetic mechanism discovery: Investigating DNA methylation variations underlying different phenotypes.
• Disease epigenetics: Studying methylation associations linked to 275 diseases for insights into disease-related epigenetic changes.
• Environmental exposure analysis: Examining epigenetic associations related to 104 environmental factors.
• Translational research and biomarker studies: Supporting efforts to derive biological insights with potential applications in translational medicine.

Methodology:

The platform compiles and normalizes DNA methylation array data and integrates curated EWAS associations, and the toolkit performs enrichment analyses, annotations, and network visualizations based on the integrated knowledgebase.