ExoCarta

ExoCarta catalogs exosomal proteins, mRNA, miRNA, and lipids to provide a comprehensive resource for analysis of exosome molecular composition and identification of molecular signatures across tissues and cell types.

Key Features:

• Curated molecular catalog: Curated listing of exosomal proteins, mRNA, miRNA, and lipid entries derived from exosomal studies.
• Content scope (v3.1): Version 3.1 contains 11,261 protein entries, 2,375 mRNA entries, and 764 miRNA entries from 134 distinct exosomal studies and includes lipid entries added in v3.1.
• Study provenance: Aggregates data from both published and unpublished exosomal studies.
• Methodological annotation: Documents methods used for exosomal purification and characterization and records biophysical and molecular properties.
• Quality assessment data: Provides information useful for assessing the quality of exosomal preparations and corresponding experimental data.
• Molecular signature support: Enables identification and comparison of molecular signatures associated with tissue- or cell type–derived exosomes.

Scientific Applications:

• Comparative composition analysis: Comparative analysis of exosomal proteomic, mRNA, miRNA, and lipid composition across studies.
• Biomarker and signature discovery: Identification of tissue- or cell type–specific exosomal molecular signatures for biomarker research.
• Quality control and reproducibility: Assessment of exosome preparation quality and evaluation of experimental reproducibility.
• Exosome biology studies: Investigation of exosome roles in intercellular communication and related biological processes.
• Therapeutic research support: Informing studies on potential therapeutic applications of exosomes based on molecular composition.

Methodology:

Meticulous curation and aggregation of published and unpublished exosomal proteomic, mRNA, miRNA, and lipid datasets with annotation of purification and characterization methods and associated biophysical and molecular properties.