ExomiRHub

ExomiRHub hosts, analyzes, and interprets human extracellular microRNA transcriptomics data through an integrated database and analytical platform.

Key Features:

• Integrated Dataset Collection: The platform incorporates 191 human extracellular miRNA expression datasets associated with 112 disease phenotypes, 62 treatments, and 24 genotypes, encompassing 29,198 miRNAs and 23 sample types, plus 16,012 miRNA transcriptomes of 156 cancer subtypes from The Cancer Genome Atlas.
• Data Standardization and Curation: All data in ExomiRHub were standardized and curated with annotations.
• Analytical Functions: The platform offers 25 analytical functions, including differential expression, co-expression, Weighted Gene Co-Expression Network Analysis (WGCNA), feature selection, and functional enrichment, with capabilities for users to select samples, define groups, and customize parameters.
• User Data Analysis: ExomiRHub provides a web service for analyzing uploaded miRNA expression data.
• miRNA Function and Target Evaluation: Four additional tools were developed to evaluate the functions and targets of miRNAs and miRNA variations.

Scientific Applications:

• Extracellular miRNA Biomarker Discovery: ExomiRHub accelerates the discovery of extracellular miRNA biomarkers, as demonstrated by identification of extracellular miRNA biomarkers associated with angiogenesis for monitoring glioma progression.
• Disease-Related Transcriptomics Analysis: The platform enables analysis of human disease-related extracellular microRNA transcriptomics data across diverse phenotypes, treatments, and genotypes.
• Cancer Subtype Analysis: ExomiRHub supports investigation of miRNA transcriptome patterns across 156 cancer subtypes from The Cancer Genome Atlas.
• miRNA Functional Characterization: The integrated tools enable evaluation of miRNA functions, targets, and miRNA variations.

Methodology:

Data were standardized and curated with annotations. Analytical functions include differential expression, co-expression, Weighted Gene Co-Expression Network Analysis (WGCNA), feature selection, and functional enrichment. Four additional tools evaluate functions and targets of miRNAs and miRNA variations.