exoRBase 2.0

exoRBase 2.0 provides a curated database and comparative expression resource of extracellular vesicle long RNAs (exLRs), cataloging 19,643 mRNAs, 15,645 long non-coding RNAs (lncRNAs), and 79,084 circular RNAs (circRNAs) derived from approximately 1,000 human blood, urine, cerebrospinal fluid (CSF), and bile samples to enable analysis of pathway-level functional changes and heterogeneity of EV origins.

Key Features:

• Comprehensive catalog: Contains 19,643 mRNAs, 15,645 lncRNAs, and 79,084 circRNAs derived from ~1,000 human blood, urine, cerebrospinal fluid, and bile samples.
• Expression integration: Integrates exLR expression profiles across physiological and pathological conditions for comparative analysis.
• Cross-biofluid comparison: Enables comparison of exLR expression among blood, urine, CSF, and bile samples.
• Pathway-level visualization: Visualizes pathway-level functional changes associated with exLR expression differences.
• EV origin heterogeneity analysis: Supports analysis of heterogeneity in the cellular or tissue origins of circulating extracellular vesicles.
• Signature identification: Facilitates identification of novel exLR signatures from human biofluids.

Scientific Applications:

• Biomarker discovery: Identification of circulating exLR signatures for disease diagnosis and therapeutic monitoring.
• Functional characterization: Investigation of pathway-level functions of mRNAs, lncRNAs, and circRNAs within extracellular vesicles.
• Comparative studies: Comparative analysis of exLR profiles across different biofluids and pathological conditions.
• Clinical research support: Support for studies linking exLRs in EVs to clinical implications relevant to precision medicine and personalized healthcare.

Methodology:

Cataloging of mRNAs, lncRNAs, and circRNAs from human blood, urine, cerebrospinal fluid, and bile samples, integration and comparison of exLR expression profiles across conditions, and visualization of pathway-level functional changes.