Expasy

Expasy provides integrated access to protein- and life-science databases and analytical tools for proteomics, genomics, phylogeny/evolution, systems biology, population genetics, and transcriptomics.

Key Features:

• Databases and repositories: Hosts databases including SWISS-PROT, TrEMBL, SWISS-2DPAGE, PROSITE, ENZYME, and the SWISS-MODEL repository.
• Proteomics analytical tools: Provides similarity searches, pattern and profile searches, post-translational modification prediction, topology prediction, and sequence alignment tools for protein analysis.
• Integration and interlinking: Interlinks database entries across SIB and partner resources and leverages SWISS-PROT annotations to inform proteomics analyses.
• Decentralized hosting: Resources are hosted by various SIB groups and partner institutions.

Scientific Applications:

• Proteomics: Supports protein sequence analysis including similarity searches, pattern/profile matching, post-translational modification prediction, and topology prediction.
• Genomics: Provides sequence alignment capabilities and access to protein-coding sequence annotations via SWISS-PROT and TrEMBL.
• Phylogeny/evolution: Enables sequence comparison and alignment for phylogenetic and evolutionary studies.
• Systems biology: Supplies interlinked databases and resources that can be incorporated into systems-level analyses.
• Population genetics: Offers sequence resources that can be applied in population-level sequence analyses.
• Transcriptomics: Provides access to protein-related annotations and sequence analysis tools relevant to transcript-derived protein studies.

Methodology:

Implements similarity searches, pattern and profile searches, post-translational modification prediction, topology prediction, sequence alignment, and interlinking of database entries using SWISS-PROT annotations.