EZCancerTarget

EZCancerTarget integrates genomic, proteomic, and pharmacological data from public databases to support drug repurposing and target validation in cancer research.

Key Features:

• Data Aggregation: Aggregates data and literature from PubChem, DrugBank, PubMed, and EMA.
• Multi-omic Integration: Integrates genomic, proteomic, and pharmacological information to generate combined molecular profiles.
• Custom Drug–Target Lists: Produces customizable drug–target lists for prioritization of clinically relevant targets for functional validation assays or drug trials.
• Biological Contextualization: Supplements compound and target entries with UniProt, String, and GeneCards annotations including pathways, molecular functions, and subcellular localization.
• Disease Focus: Incorporates content and expertise relevant to small-cell lung cancer (SCLC), triple-negative breast cancer, and pancreatic cancer.

Scientific Applications:

• Drug Repurposing: Supports identification and prioritization of existing compounds for new cancer indications using aggregated pharmacological and literature evidence.
• Target Validation: Provides compiled molecular, pathway, and literature data to support experimental and clinical target validation.
• Prioritization for Assays and Trials: Enables selection of clinically relevant targets for functional validation assays or drug trials.
• Systematic Retrieval: Facilitates systematic searches and data retrieval for targets and compounds across PubChem, DrugBank, PubMed, and EMA.

Methodology:

Aggregates and integrates genomic, proteomic, and pharmacological data from PubChem, DrugBank, PubMed, EMA, UniProt, String, and GeneCards to produce compound- and target-centric profiles.