FamAgg

FamAgg analyzes familial aggregation of traits in large pedigrees to quantify trait clustering and support selection of families for genetic follow-up studies.

Key Features:

• Pedigree analysis and plotting utilities: Provides utilities for pedigree analysis and visualization to manage and interpret complex family structures.
• Familial aggregation methods: Implements methods to evaluate trait aggregation at both family and individual levels.
• Established and novel methodologies: Includes both established and novel methods to quantify familial aggregation.
• Large pedigree handling: Handles very large pedigrees comprising thousands of participants across numerous families.

Scientific Applications:

• Assessing genetic contribution: Quantifies familial clustering of traits to assess genetic contributions to diseases.
• Family selection for follow-up: Guides selection of families for detailed genetic follow-up studies.
• Demonstration on cancer data: Applied to a public cancer dataset comprising over 20,000 participants across approximately 400 families.

Methodology:

Calculates measures that express trait distribution at family and individual levels using both established and novel aggregation methods.