FamFetch

FamFetch queries homologous gene family databases to identify orthologs and paralogs and to provide gene sequences, multiple sequence alignments, and phylogenetic trees for comparative sequence analysis of genome function and evolution.

Key Features:

• Automated Searches: Performs automated searches for orthologs and paralogs within databases derived from the HOBACGEN model.
• Comprehensive Data Access: Retrieves gene sequences, multiple sequence alignments, and phylogenetic trees from HOBACGEN, HOVERGEN, and HOGENOM.
• HOBACGEN Model Integration: Operates with databases developed using the HOBACGEN model to support comparative sequence analysis.

Scientific Applications:

• Genomic Studies: Understanding the functional implications of genetic variations by mapping homologous genes.
• Evolutionary Biology: Tracing gene evolution and identifying orthologous and paralogous relationships among species.
• Comparative Genomics: Analyzing homologous genes across organisms to infer common ancestry and divergent functions.

Methodology:

Performs automated searches for orthologs and paralogs against databases developed with the HOBACGEN model and retrieves gene sequences, multiple sequence alignments, and phylogenetic trees from HOBACGEN, HOVERGEN, and HOGENOM.