Fantastic databases and where find them

Fantastic databases and where find them catalogs and organizes references to public biological databases to facilitate access to human-focused omics data and support multi-omics analyses.

Key Features:

• Curated omics collection: Provides a curated listing of public biological databases covering human-focused omics datasets.
• Entity coverage: Indexes resources that include biological sequences, genes, genomes, gene expression patterns, epigenetic variations, protein-protein interactions, variant frequencies, and regulatory elements.
• Comparative analyses: Includes resources for comparative analyses between humans and model organisms.
• Multi-omics integration: Supports integration of multiple datasets to enable combined analyses across omics types.
• Data management: Facilitates systematic storage and management of large-scale biological data.
• Data mining and retrieval: Enables data mining and information retrieval across aggregated resources.
• ACE2 case study: Presents an illustrative case study on ACE2 demonstrating database-based analyses across sequence, expression, epigenetic, and interaction data.

Scientific Applications:

• Multi-omics tool development: Serves as a resource base for building and testing multi-omics analytical tools.
• Genetic disease research: Supports diagnosis, prognosis, and therapeutic discovery efforts for genetic diseases by integrating variant frequencies and functional data.
• Comparative genomics: Enables comparative analyses between humans and model organisms for functional inference.
• Gene-specific investigations: Facilitates detailed analyses of genes such as ACE2 across sequence, expression, epigenetic, and interaction datasets.

Methodology:

Manually curated aggregation of public biological databases, integration of multiple datasets, and support for data mining, information retrieval, and comparative analyses between humans and model organisms.