FASTM (EBI)

FASTM (EBI) performs peptide-fragment sequence similarity searches to detect homologous protein sequences and support protein function inference and evolutionary analyses.

Key Features:

• Sequence similarity search: Performs peptide fragment searches to identify similarities between protein sequences.
• FASTA suite membership: Operates as part of the FASTA suite, including FASTF, FASTM, and FASTS.
• Integration with EMBL-EBI Job Dispatcher: Integrated into the EMBL-EBI Job Dispatcher sequence analysis tools framework (https://www.ebi.ac.uk/jdispatcher) and accessible programmatically via RESTful and SOAP APIs.
• Access to EMBL-EBI data resources: Connects to UniProt, InterPro, ENA, and Ensembl Genomes for up-to-date sequence datasets.
• Sensitivity and specificity: Utilizes algorithms aimed at high sensitivity and specificity in sequence similarity detection.

Scientific Applications:

• Protein Function Analysis: Enables inference of functional relationships between proteins through detected sequence similarity.
• Evolutionary Studies: Facilitates comparison of peptide fragments across species to investigate evolutionary relationships.
• Disease Research: Supports comparison of pathogenic or disease-related sequences to study genetic bases of disease.

Methodology:

Performs peptide fragment searches using advanced algorithms within the FASTA suite and is integrated with the EMBL-EBI Job Dispatcher for processing, with programmatic access via RESTful and SOAP APIs.