FaviCoV

FaviCoV curates functionally relevant genetic variants in the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) genome to support analysis of their functional consequences.

Key Features:

• Comprehensive Variant Compilation: Contains 1653 genetic variant records from SARS-CoV-2 genomes, representing 1348 unique variants and 154 variants with experimental evidence compiled via manual curation of literature and preprints.
• Functional Annotation: Annotates each variant with descriptions of functional relevance, including the types of assays used to determine functionality and interpretations of assay results.
• Experimental Evidence Association: Identifies and associates variants with reported experimental validation and the corresponding experimental findings from the literature.

Scientific Applications:

• Genetic Epidemiology: Provides variant-level functional information to inform analyses of viral evolutionary dynamics and epidemiological patterns.
• Variant Impact Studies: Enables investigation of how specific variants influence SARS-CoV-2 characteristics such as transmissibility, virulence, and immune escape.
• Vaccine and Therapeutic Assessment: Supplies functional variant data relevant to evaluating and prioritizing impacts on vaccine and therapeutic efficacy.

Methodology:

Manual compilation of variants and associated evidence from literature and preprints, with annotation of variants using reported experimental assay results.